Tumor-targeted gene delivery of tumor necrosis factor-alpha induces tumor necrosis and tumor regression without systemic toxicity.

Kircheis, Ralf; Ostermann, Elinborg; Wolschek, Markus F; Lichtenberger, Cornelia; Magin-Lachmann, Christine; Wightman, Lionel; Kursa, Malgorzata; Wagner, Ernst

Kircheis, Ralf; Ostermann, Elinborg; Wolschek, Markus F; Lichtenberger, Cornelia; Magin-Lachmann, Christine; Wightman, Lionel; Kursa, Malgorzata; Wagner, Ernst.

Affiliation

Kircheis R; Boehringer Ingelheim Austria, Vienna, Austria. ralf.kircheis@igeneon.com

Cancer Gene Ther ; 9(8): 673-80, 2002 Aug.

Article in En | MEDLINE | ID: mdl-12136428

Subject(s)

Neuroblastoma/pathology; Tumor Necrosis Factor-alpha/genetics; Animals; Fibrosarcoma/genetics; Fibrosarcoma/pathology; Genetic Therapy; Melanoma, Experimental/genetics; Melanoma, Experimental/pathology; Mice; Neuroblastoma/genetics; Neuroblastoma/metabolism; Neuroblastoma/therapy; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Neuroblastoma Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Gene Ther Journal subject: GENETICA MEDICA / NEOPLASIAS / TERAPEUTICA Year: 2002 Document type: Article Affiliation country: Austria Country of publication: United kingdom

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