Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).

Levy, Bruce D; De Sanctis, George T; Devchand, Pallavi R; Kim, Eugene; Ackerman, Kate; Schmidt, Birgitta A; Szczeklik, Wojciech; Drazen, Jeffrey M; Serhan, Charles N

Levy, Bruce D; De Sanctis, George T; Devchand, Pallavi R; Kim, Eugene; Ackerman, Kate; Schmidt, Birgitta A; Szczeklik, Wojciech; Drazen, Jeffrey M; Serhan, Charles N.

Affiliation

Levy BD; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Nat Med ; 8(9): 1018-23, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12172542

Subject(s)

Asthma/drug therapy; Bronchial Hyperreactivity/drug therapy; Bronchitis/drug therapy; Hydroxyeicosatetraenoic Acids/pharmacology; Lipoxins; Receptors, Formyl Peptide; Receptors, Lipoxin; Animals; Asthma/diagnosis; Asthma/metabolism; Asthma/physiopathology; Chemokine CCL11; Chemokines, CC/metabolism; Eosinophils/drug effects; Eosinophils/metabolism; Eosinophils/pathology; Interleukin-13/metabolism; Interleukin-5/metabolism; Leukotrienes/metabolism; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandins/metabolism; Receptors, Cell Surface/drug effects; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Bronchitis / Hydroxyeicosatetraenoic Acids / Bronchial Hyperreactivity / Lipoxins / Receptors, Lipoxin / Receptors, Formyl Peptide Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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