The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells.

Hwang, Shin-Rong; Steineckert, Brent; Toneff, Thomas; Bundey, Richard; Logvinova, Anna V; Goldsmith, Paul; Hook, Vivian Y H

Hwang, Shin-Rong; Steineckert, Brent; Toneff, Thomas; Bundey, Richard; Logvinova, Anna V; Goldsmith, Paul; Hook, Vivian Y H.

Affiliation

Hwang SR; Buck Institute for Age Research, Novato, California 94945, USA.

Biochemistry ; 41(33): 10397-405, 2002 Aug 20.

Article in En | MEDLINE | ID: mdl-12173926

Subject(s)

Chromaffin Granules/metabolism; Cysteine Proteinase Inhibitors/pharmacology; Neurosecretory Systems/metabolism; Pancreatic Elastase/antagonists & inhibitors; Papain/antagonists & inhibitors; Secretory Vesicles/metabolism; Serine Proteinase Inhibitors/pharmacology; Serpins/physiology; Amino Acid Sequence; Animals; Cattle; Chromaffin Granules/enzymology; Humans; Kinetics; Molecular Sequence Data; Neurosecretory Systems/enzymology; Pancreatic Elastase/metabolism; Papain/metabolism; Rabbits; Recombinant Fusion Proteins/biosynthesis; Secretory Vesicles/enzymology; Serpins/biosynthesis; Serpins/metabolism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Elastase / Papain / Cysteine Proteinase Inhibitors / Serine Proteinase Inhibitors / Serpins / Chromaffin Granules / Secretory Vesicles / Neurosecretory Systems Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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