Vascular effects of GI262570X (PPAR-gamma agonist) in the brown adipose tissue of Han Wistar rats: a review of 1-month, 13-week, 27-week and 2-year oral toxicity studies.

Elangbam, Chandikumar S; Brodie, Thomas A; Brown, H Roger; Nold, James B; Raczniak, Timothy J; Tyler, Ronald D; Lightfoot, Ruth M; Wall, Henry G

Elangbam, Chandikumar S; Brodie, Thomas A; Brown, H Roger; Nold, James B; Raczniak, Timothy J; Tyler, Ronald D; Lightfoot, Ruth M; Wall, Henry G.

Affiliation

Elangbam CS; Department of Pathology, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA. cse63957@gsk.com

Toxicol Pathol ; 30(4): 420-6, 2002.

Article in En | MEDLINE | ID: mdl-12187934

Subject(s)

Adipose Tissue, Brown/drug effects; Hypoglycemic Agents/toxicity; Muscle, Smooth, Vascular/drug effects; Oxazoles; Adipose Tissue, Brown/blood supply; Animals; Arteriosclerosis/chemically induced; Cell Division/drug effects; Female; Male; Muscle, Smooth, Vascular/pathology; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear/physiology; Time Factors; Transcription Factors/physiology; Tyrosine/analogs & derivatives

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Adipose Tissue, Brown / Hypoglycemic Agents / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Toxicol Pathol Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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