Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.

Posner, Gary H; Jeon, Heung Bae; Ploypradith, Poonsakdi; Paik, Ik-Hyeon; Borstnik, Kristina; Xie, Suji; Shapiro, Theresa A

Posner, Gary H; Jeon, Heung Bae; Ploypradith, Poonsakdi; Paik, Ik-Hyeon; Borstnik, Kristina; Xie, Suji; Shapiro, Theresa A.

Affiliation

Posner GH; Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218-2685, USA. gposner1@hem.jhu.edu

J Med Chem ; 45(18): 3824-8, 2002 Aug 29.

Article in En | MEDLINE | ID: mdl-12190305

Subject(s)

Antimalarials/chemical synthesis; Benzoates/chemical synthesis; Benzoxepins/chemical synthesis; Administration, Oral; Animals; Antimalarials/chemistry; Antimalarials/pharmacology; Benzoates/chemistry; Benzoates/pharmacology; Benzoxepins/chemistry; Benzoxepins/pharmacology; Malaria/drug therapy; Mice; Plasmodium berghei; Solubility; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzoates / Benzoxepins / Antimalarials Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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