The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation.

Attema, Joanne L; Reeves, Raymond; Murray, Vincent; Levichkin, Ilya; Temple, Mark D; Tremethick, David J; Shannon, M Frances

Attema, Joanne L; Reeves, Raymond; Murray, Vincent; Levichkin, Ilya; Temple, Mark D; Tremethick, David J; Shannon, M Frances.

Affiliation

Attema JL; Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.

J Immunol ; 169(5): 2466-76, 2002 Sep 01.

Article in En | MEDLINE | ID: mdl-12193716

Subject(s)

Interleukin-2/genetics; Lymphocyte Activation/genetics; Nucleosomes/genetics; Nucleosomes/immunology; Promoter Regions, Genetic/immunology; T-Lymphocytes/immunology; CD28 Antigens/genetics; CD28 Antigens/immunology; CD28 Antigens/metabolism; Chromatin/genetics; Chromatin/immunology; Chromatin/metabolism; DNA Footprinting; DNA, Neoplasm/analysis; HMGA1a Protein/metabolism; Humans; Jurkat Cells; Nucleosomes/metabolism; Polymerase Chain Reaction/methods; Protein Binding/genetics; Protein Binding/immunology; Protein Biosynthesis/immunology; Response Elements/immunology; T-Lymphocytes/metabolism; Transcription Factors/antagonists & inhibitors; Transcription Factors/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Nucleosomes / T-Lymphocytes / Interleukin-2 / Promoter Regions, Genetic Limits: Humans Language: En Journal: J Immunol Year: 2002 Document type: Article Affiliation country: Australia

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