Comm sorts robo to control axon guidance at the Drosophila midline.
Cell
; 110(4): 415-27, 2002 Aug 23.
Article
in En
| MEDLINE
| ID: mdl-12202032
ABSTRACT
Axon growth across the Drosophila midline requires Comm to downregulate Robo, the receptor for the midline repellent Slit. We show here that comm is required in neurons, not in midline cells as previously thought, and that it is expressed specifically and transiently in commissural neurons. Comm acts as a sorting receptor for Robo, diverting it from the synthetic to the late endocytic pathway. A conserved cytoplasmic LPSY motif is required for endosomal sorting of Comm in vitro and for Comm to downregulate Robo and promote midline crossing in vivo. Axon traffic at the CNS midline is thus controlled by the intracellular trafficking of the Robo guidance receptor, which in turn depends on the precisely regulated expression of the Comm sorting receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Immunologic
/
Cell Differentiation
/
Central Nervous System
/
Gene Expression Regulation, Developmental
/
Growth Cones
/
Protein Transport
/
Drosophila Proteins
/
Drosophila melanogaster
/
Membrane Proteins
Type of study:
Guideline
Language:
En
Journal:
Cell
Year:
2002
Document type:
Article
Affiliation country:
Austria