Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamine.

Pereira, F C; Imam, S Z; Gough, B; Newport, G D; Ribeiro, C F; Slikker, W; Macedo, T R; Ali, S F

Pereira, F C; Imam, S Z; Gough, B; Newport, G D; Ribeiro, C F; Slikker, W; Macedo, T R; Ali, S F.

Affiliation

Pereira FC; Neurochemistry Laboratory, Division of Neurotoxicology, NCTR, Jefferson 72079, AR, USA.

J Neural Transm (Vienna) ; 109(9): 1151-8, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12203042

ABSTRACT

ABSTRACT

Acute changes in dopamine (DA) turnover were studied in the caudate nucleus (CN) of adult male rats between 0-24 h after a single injection of Methamphetamine (20 mg/kg, ip). A single dose of METH-induced an increase in DA turnover [(DOPAC + HVA)/DA] concomitant with an acute DA release followed by transient DA and DOPAC depletion in the rat CN.

Subject(s)

Amphetamine-Related Disorders/metabolism; Caudate Nucleus/drug effects; Dopamine Uptake Inhibitors/pharmacology; Dopamine/metabolism; Methamphetamine/pharmacology; Presynaptic Terminals/drug effects; 3,4-Dihydroxyphenylacetic Acid/metabolism; Acute Disease; Amphetamine-Related Disorders/physiopathology; Animals; Caudate Nucleus/metabolism; Dose-Response Relationship, Drug; Down-Regulation/drug effects; Down-Regulation/physiology; Drug Administration Schedule; Homovanillic Acid/metabolism; Male; Presynaptic Terminals/metabolism; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Dopamine / Caudate Nucleus / Presynaptic Terminals / Dopamine Uptake Inhibitors / Amphetamine-Related Disorders / Methamphetamine Limits: Animals Language: En Journal: J Neural Transm (Vienna) Year: 2002 Document type: Article Affiliation country: United States

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