T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction.
Lab Invest
; 82(9): 1103-9, 2002 Sep.
Article
in En
| MEDLINE
| ID: mdl-12218070
ABSTRACT
The atypical cells of CD30(+) cutaneous lymphoproliferative disorders (CD30CLD) are commonly of T-cell origin and frequently have a similar morphology as Hodgkin or Reed-Sternberg cells of Hodgkin's lymphoma (HL). HL is one of the tumors associated with CD30CLD. Although most studies support a B-cell derivation of the tumor cells in HL, recently a few cases of classical HL with T-cell genotype have been reported. We report a patient who presented with CD30CLD whose lymph nodes showed classical HL of mixed cellularity subtype at presentation. By single-cell PCR, the same clonal gene rearrangements of the T cell receptor-beta gene locus could be assigned to the CD30(+) and CD15(+) cells of both skin and lymph node. In a lymph node biopsy specimen taken in relapse after several courses of chemotherapy, the CD30(+) tumor cells were abundant. The T cell-derived tumor cells displayed aberrant expression of the Pax-5 gene in all specimens. A common clonal origin of both CD30CLD and HL of the lymph node in the patient presented here suggests that HL with T-cell genotype exists in association with CD30CLD as well as in sporadic cases and may share clonal origin with the skin tumor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases
/
Hodgkin Disease
/
Polymerase Chain Reaction
/
Lymphoma, T-Cell
/
Ki-1 Antigen
/
Lymph Nodes
/
Lymphoproliferative Disorders
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Lab Invest
Year:
2002
Document type:
Article
Affiliation country:
Germany