Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice.

Shealy, David J; Wooley, Paul H; Emmell, Eva; Volk, Amy; Rosenberg, Amy; Treacy, George; Wagner, Carrie L; Mayton, Lois; Griswold, Don E; Song, Xiao-Yu R

Shealy, David J; Wooley, Paul H; Emmell, Eva; Volk, Amy; Rosenberg, Amy; Treacy, George; Wagner, Carrie L; Mayton, Lois; Griswold, Don E; Song, Xiao-Yu R.

Affiliation

Shealy DJ; Centocor, Inc, Malvern, Pennsylvania, USA. dshealy@cntus.jnj.com

Arthritis Res ; 4(5): R7, 2002.

Article in En | MEDLINE | ID: mdl-12223110

Subject(s)

Antibodies, Monoclonal/therapeutic use; Arthritis, Rheumatoid/therapy; Joints/pathology; Tumor Necrosis Factor-alpha/immunology; Animals; Arthritis, Rheumatoid/metabolism; Arthritis, Rheumatoid/pathology; Chemokines/genetics; Chemokines/metabolism; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Forearm/pathology; Heterozygote; Hindlimb/pathology; Joints/drug effects; Mice; Mice, Transgenic; RNA, Messenger/metabolism; Tumor Necrosis Factor-alpha/analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Tumor Necrosis Factor-alpha / Joints / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arthritis Res Journal subject: REUMATOLOGIA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United kingdom

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