New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.

Orús, L; Martínez, J; Pérez, S; Oficialdegui, A M; del Castillo, J C; Mourelle, M; Lasheras, B; del Río, J; Monge, A

Orús, L; Martínez, J; Pérez, S; Oficialdegui, A M; del Castillo, J C; Mourelle, M; Lasheras, B; del Río, J; Monge, A.

Affiliation

Orús L; Department of Medicinal Chemistry, Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, Pamplona, Spain.

Pharmazie ; 57(8): 515-8, 2002 Aug.

Article in En | MEDLINE | ID: mdl-12227188

Subject(s)

Antidepressive Agents, Second-Generation/chemical synthesis; Antidepressive Agents, Second-Generation/pharmacology; Carrier Proteins/drug effects; Membrane Glycoproteins/drug effects; Membrane Transport Proteins; Nerve Tissue Proteins; Propanols/chemistry; Receptors, Serotonin/drug effects; Thiophenes/chemistry; Antidepressive Agents, Second-Generation/metabolism; Indicators and Reagents; Kinetics; Protein Binding; Receptors, Serotonin, 5-HT1; Serotonin Plasma Membrane Transport Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Thiophenes / Membrane Glycoproteins / Carrier Proteins / Receptors, Serotonin / Antidepressive Agents, Second-Generation / Propanols / Nerve Tissue Proteins Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2002 Document type: Article Affiliation country: Spain

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