Antifertility treating with long term gossypol.
Adv Contracept Deliv Syst
; 3(2-3): 181, 1987.
Article
in En
| MEDLINE
| ID: mdl-12268655
ABSTRACT
PIP In the 1974-86 period, gossypol acetate was taken as an antifertility measure by 16 men. The initial dose was 20 mg/day, with a maintenance dose of 40 mg/week. Antifertility efficacy was obtained in all 16 cases. Azoospermia persisted in 1 case where the gossypol had been taken for 8 years and discontinued for the past 2 1/2 years. Symptoms experienced in the first 2 weeks of gossypol acetate administration included dizziness, anorexia, nausea, fatigue, and stomach discomfort. Results of examinations of blood and urine; functions of the heart, liver, lung, and liver; electrolytes; external genitalia; and sexual performance were all in the normal range. Measurements of semen, plasma biochemistry, and endocrine changes also were within normal limits. However, in the 9 cases in which the average value of plasma testosterone was near the lower limit of normal, the average value of follicle-stimulating hormone was higher than normal and the testosterone/luteinizing hormone ratio was unusually low. Testis biopsy indicated that long-term gossypol treatment affected both germ cells and Sertoli cells. Leydig cells also demonstrated some damage. Gossypol acetate is, in general, considered an ideal male contraceptive because of its long-term effectiveness, reversibility, and lack of severe toxic side effects.^ieng
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Research
/
Gossypol
/
Contraception
/
Contraceptive Agents, Male
/
Family Planning Services
Language:
En
Journal:
Adv Contracept Deliv Syst
Year:
1987
Document type:
Article