Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.

Dittmar, Thomas; Husemann, Anja; Schewe, Yvonne; Nofer, Jerzy-Roch; Niggemann, Bernd; Zänker, Kurt S; Brandt, Burkhard H

Dittmar, Thomas; Husemann, Anja; Schewe, Yvonne; Nofer, Jerzy-Roch; Niggemann, Bernd; Zänker, Kurt S; Brandt, Burkhard H.

Affiliation

Dittmar T; Institute of Immunology, University of Witten/Herdecke, Stockumer Str. 10, 58448 Witten, Germany. thomasd@uni-wh.de

FASEB J ; 16(13): 1823-5, 2002 Nov.

Article in En | MEDLINE | ID: mdl-12354693

Subject(s)

Cell Movement/drug effects; Epidermal Growth Factor/pharmacology; ErbB Receptors/metabolism; Receptor, ErbB-2/metabolism; Calcium/metabolism; Dimerization; Enzyme Activation/drug effects; ErbB Receptors/chemistry; Estrenes/pharmacology; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Phosphodiesterase Inhibitors/pharmacology; Phospholipase C gamma; Phosphorylation/drug effects; Pyrrolidinones/pharmacology; Receptor, ErbB-2/chemistry; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases/antagonists & inhibitors; Type C Phospholipases/metabolism; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Receptor, ErbB-2 / Epidermal Growth Factor / ErbB Receptors Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2002 Document type: Article Affiliation country: Germany Country of publication: United States

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