Quality of life in multiple sclerosis: influence of interferon-beta1 a (Avonex) treatment.
Mult Scler
; 8(5): 377-81, 2002 Oct.
Article
in En
| MEDLINE
| ID: mdl-12356203
ABSTRACT
BACKGROUND:
Numerous data argue for initiating treatment with interferon-beta (IFN-beta) at an early stage in multiple sderosis (MS). The consequences of its use may negatively influence the MS patient's quality of life (QoL).OBJECTIVE:
To evaluate the QoL of MS patients before and after a one-year period of treatment with IFN-beta1a (Avonex). PATIENTS ANDMETHODS:
QoL was assessed using the SF-36 in 121 relapsing-remitting MS patients. We compared QoL before and after treatment and with data from a normal population. We also studied the possible influence of disease progression on the SF-36 scores.RESULTS:
One hundred six patients completed the study (87%). Compared to a normal population, patients were, at baseline, worse off for all QoL scales, varying from a minimum decrease of 0.73 SD in mental health, to a maximum decrease of 1.55 SD in general health. After treatment, we found no significant changes in any of the QoL scores, except for physical function, where we noted a slight but significant decrease (p = 0.03). Furthermore, there was no significant change either in the physical component summary (PCS) or mental component summary (MCS). The 'reported health transition' item was significantly improved compared to baseline (p = 0.001). At indusion, significant correlations were found between EDSS scores and scores of physical function (p < 0.001), role - physical (p < 0.01), general health and social function (both p < 0.01), and with the PCS (p < 0.01). Patients with dinical relapses and/or disability progression had a more significant decease in physical function (p < 0.05) and also in social function (p < 0.05).CONCLUSION:
The QoL, assessed by the SF-36 scale, is correlated with disability in MS. IFN-beta1a treatment (Avonex) has no negative effect on MS patient's QoL.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Adjuvants, Immunologic
/
Interferon-beta
/
Multiple Sclerosis, Relapsing-Remitting
Aspects:
Patient_preference
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2002
Document type:
Article
Affiliation country:
France