Second HLA-A*68 null allele, A*6818 N, identified.
Tissue Antigens
; 60(1): 88-90, 2002 Jul.
Article
in En
| MEDLINE
| ID: mdl-12366788
ABSTRACT
A second HLA-A*68 null allele, HLA-A*6818 N, was identified in our laboratory after discrepant results were obtained between class I serological and molecular typing in a male patient suffering from narcolepsy. HLA-A*6818 N displays a sequence identical to that of the HLA-A*6802 allele, except in exon 2 where 20 nucleotides inserted at codon position 48 are a repeat of the 20 preceding nucleotides. This duplication creates a shift of the reading frame, which leads to a premature non-sense codon at position 59 of the null allele.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HLA-A Antigens
/
Alleles
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Tissue Antigens
Year:
2002
Document type:
Article
Affiliation country:
France