The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.
Bioorg Med Chem Lett
; 12(21): 3171-4, 2002 Nov 04.
Article
in En
| MEDLINE
| ID: mdl-12372526
ABSTRACT
The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Staphylococcus aureus
/
Tryptophan-tRNA Ligase
/
Enzyme Inhibitors
/
Indoles
/
Anti-Bacterial Agents
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2002
Document type:
Article
Affiliation country:
United kingdom