Dual NK(1) antagonists--serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives.

Ryckmans, Thomas; Berton, Olivier; Grimée, Renée; Kogej, Thierry; Lamberty, Yves; Pasau, Patrick; Talaga, Patrice; Genicot, Christophe

Ryckmans, Thomas; Berton, Olivier; Grimée, Renée; Kogej, Thierry; Lamberty, Yves; Pasau, Patrick; Talaga, Patrice; Genicot, Christophe.

Affiliation

Ryckmans T; Chemical Research, R&D, UCB Pharma SA, Chemin du Foriest, B-1420, Braine-l'Alleud, Belgium. thomas_ryckmans@sandwich.pfizer.com

Bioorg Med Chem Lett ; 12(21): 3195-8, 2002 Nov 04.

Article in En | MEDLINE | ID: mdl-12372532

Subject(s)

Antidepressive Agents, Second-Generation/chemical synthesis; Antidepressive Agents, Second-Generation/pharmacology; Membrane Transport Proteins; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Piperazines/chemical synthesis; Piperazines/pharmacology; Selective Serotonin Reuptake Inhibitors/chemical synthesis; Selective Serotonin Reuptake Inhibitors/pharmacology; Alcohols/chemical synthesis; Alcohols/pharmacology; Carrier Proteins/drug effects; Central Nervous System/drug effects; Central Nervous System/metabolism; Drug Evaluation, Preclinical; Humans; Membrane Glycoproteins/drug effects; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Piperazines / Selective Serotonin Reuptake Inhibitors / Antidepressive Agents, Second-Generation / Neurokinin-1 Receptor Antagonists / Nerve Tissue Proteins Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: Belgium

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