AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.

McCrimmon, R J; Evans, M L; Jacob, R J; Fan, X; Zhu, Y; Shulman, G I; Sherwin, R S

McCrimmon, R J; Evans, M L; Jacob, R J; Fan, X; Zhu, Y; Shulman, G I; Sherwin, R S.

Affiliation

McCrimmon RJ; Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Am J Physiol Endocrinol Metab ; 283(5): E1076-83, 2002 Nov.

Article in En | MEDLINE | ID: mdl-12376337

Subject(s)

Aminoimidazole Carboxamide/analogs & derivatives; Aminoimidazole Carboxamide/pharmacology; Diabetes Mellitus, Type 1/drug therapy; Glucagon/metabolism; Hypoglycemia/metabolism; Hypoglycemic Agents/pharmacology; Phlorhizin/pharmacology; Ribonucleotides/pharmacology; Animals; Blood Glucose/metabolism; Diabetes Mellitus, Type 1/metabolism; Epinephrine/blood; Epinephrine/metabolism; Glucagon/blood; Hypoglycemia/chemically induced; Insulin/blood; Norepinephrine/blood; Norepinephrine/metabolism; Rats; Rats, Inbred BB

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Collection: 01-internacional Database: MEDLINE Main subject: Phlorhizin / Ribonucleotides / Glucagon / Diabetes Mellitus, Type 1 / Aminoimidazole Carboxamide / Hypoglycemia / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2002 Document type: Article Affiliation country: United States

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