Frontal white matter microstructure and treatment response of late-life depression: a preliminary study.
Am J Psychiatry
; 159(11): 1929-32, 2002 Nov.
Article
in En
| MEDLINE
| ID: mdl-12411231
ABSTRACT
OBJECTIVE:
This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression.METHOD:
Thirteen older patients with major depression received open, but controlled, treatment with citalopram at a target daily dose of 40 mg for 12 weeks. Diffusion tensor imaging was used to determine fractional anisotropy in preselected white matter regions.RESULTS:
Survival analysis with Cox's proportional hazards model revealed that lower fractional anisotropy of the right and the left frontal white matter regions 15 mm above the anterior commissure-posterior commissure plane was associated with a low remission rate after age was considered. Remission was not significantly associated with fractional anisotropy of lower frontal regions or a temporal region.CONCLUSIONS:
Microstructural white matter abnormalities lateral to the anterior cingulate may be associated with a low rate of remission of geriatric depression.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Citalopram
/
Corpus Striatum
/
Depressive Disorder, Major
/
Dominance, Cerebral
/
Frontal Lobe
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Psychiatry
Year:
2002
Document type:
Article
Affiliation country:
United States