[Mechanisms of lability of neurological symptoms in multiple sclerosis]. / Mekhanizmy labil'nosti nevrologicheskikh simptomov pri rasseiannom skleroze.
Zh Nevrol Psikhiatr Im S S Korsakova
; Suppl: 15-9, 2002.
Article
in Ru
| MEDLINE
| ID: mdl-12418387
ABSTRACT
Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body temperature may cause changes in impulse conduction in demyelinated fibres, which was proved by studies of evoked potentials and stabilometric studies. These disturbances may be associated with disorder of ions channels function. The role of other factors (metabolic and immunological disturbances, levels of cytokines and neurotransmitters) in temporary block of nerve conduction in MS is discussed. Further studies of the mechanisms of the lability of neurological sings in MS may lead to elaboration of new approaches to MS treatment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multiple Sclerosis
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Ru
Journal:
Zh Nevrol Psikhiatr Im S S Korsakova
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
2002
Document type:
Article