Hypoglycaemic effect of a novel insulin buccal formulation on rabbits.

Xu, Hui-Bi; Huang, Kai-Xun; Zhu, Yu-Shan; Gao, Qiu-Hua; Wu, Qing-Zhi; Tian, Wei-Qun; Sheng, Xi-Qun; Chen, Ze-Xian; Gao, Zhong-Hong

Xu, Hui-Bi; Huang, Kai-Xun; Zhu, Yu-Shan; Gao, Qiu-Hua; Wu, Qing-Zhi; Tian, Wei-Qun; Sheng, Xi-Qun; Chen, Ze-Xian; Gao, Zhong-Hong.

Affiliation

Xu HB; Institute of Pharmacy, Huazhong University of Science & Technology, 430074 Wuhan, PR China. hbxu@mail.hust.edu.cn

Pharmacol Res ; 46(5): 459-67, 2002 Nov.

Article in En | MEDLINE | ID: mdl-12419651

Subject(s)

Blood Glucose/drug effects; Diabetes Mellitus, Experimental/metabolism; Hypoglycemic Agents/administration & dosage; Insulin/administration & dosage; Administration, Buccal; Adsorption; Animals; Area Under Curve; Biological Availability; Blood Glucose/analysis; Diabetes Mellitus, Experimental/drug therapy; Excipients/chemistry; Female; Hypoglycemic Agents/chemistry; Hypoglycemic Agents/pharmacokinetics; Insulin/chemistry; Insulin/pharmacokinetics; Male; Mouth Mucosa/metabolism; Phosphatidylcholines/chemistry; Propylene Glycols/chemistry; Rabbits; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Diabetes Mellitus, Experimental / Hypoglycemic Agents / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2002 Document type: Article Country of publication: Netherlands

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