Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.

Varin, Audrey; Manna, Sunil K; Quivy, Vincent; Decrion, Anne-Zélie; Van Lint, Carine; Herbein, Georges; Aggarwal, Bharat B

Varin, Audrey; Manna, Sunil K; Quivy, Vincent; Decrion, Anne-Zélie; Van Lint, Carine; Herbein, Georges; Aggarwal, Bharat B.

Affiliation

Varin A; Department of Virology and Institut d'Etude et de Transfert de Gènes, Franche-Comté University, F-25030 Besançon, France.

J Biol Chem ; 278(4): 2219-27, 2003 Jan 24.

Article in En | MEDLINE | ID: mdl-12419805

Subject(s)

Acquired Immunodeficiency Syndrome/virology; Gene Products, nef/physiology; HIV/metabolism; Mitogen-Activated Protein Kinases/metabolism; Monocytes/enzymology; NF-kappa B/metabolism; Transcription Factor AP-1/metabolism; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; Monocytes/virology; Signal Transduction; Simian Immunodeficiency Virus/metabolism; Time Factors; U937 Cells; Virus Replication/genetics; nef Gene Products, Human Immunodeficiency Virus

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Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Gene Products, nef / NF-kappa B / Acquired Immunodeficiency Syndrome / HIV / Transcription Factor AP-1 / Mitogen-Activated Protein Kinases Type of study: Etiology_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2003 Document type: Article Affiliation country: France Country of publication: United States

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