Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice.

Alberts, P; Engblom, L; Edling, N; Forsgren, M; Klingström, G; Larsson, C; Rönquist-Nii, Y; Ohman, B; Abrahmsén, L

Alberts, P; Engblom, L; Edling, N; Forsgren, M; Klingström, G; Larsson, C; Rönquist-Nii, Y; Ohman, B; Abrahmsén, L.

Affiliation

Alberts P; Pharmacology 2, Department of Biology, Research, Biovitrum, Stockholm, Sweden. peteris.alberts@biovitrum.com

Diabetologia ; 45(11): 1528-32, 2002 Nov.

Article in En | MEDLINE | ID: mdl-12436336

Subject(s)

Blood Glucose/metabolism; Enzyme Inhibitors/pharmacology; Hydroxysteroid Dehydrogenases/antagonists & inhibitors; Hyperglycemia/blood; Piperazines/pharmacology; Sulfonamides/pharmacology; Thiazoles/pharmacology; 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Base Sequence; DNA Primers; Hydroxysteroid Dehydrogenases/genetics; Hyperglycemia/enzymology; Liver/drug effects; Liver/enzymology; Male; Mice; Phosphoenolpyruvate Carboxykinase (GTP)/genetics; Polymerase Chain Reaction; RNA, Messenger/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Sulfonamides / Thiazoles / Blood Glucose / Enzyme Inhibitors / Hydroxysteroid Dehydrogenases / Hyperglycemia Limits: Animals Language: En Journal: Diabetologia Year: 2002 Document type: Article Affiliation country: Sweden

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