Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.

Braña, Miguel F; Guisado, Cristina; Fernando Alguacil, Luis; Garrido, Elisa; Pérez-García, Carmen; Ruiz-Gayo, Mariano

Braña, Miguel F; Guisado, Cristina; Fernando Alguacil, Luis; Garrido, Elisa; Pérez-García, Carmen; Ruiz-Gayo, Mariano.

Affiliation

Braña MF; Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain. mfbrana@ceu.es

Bioorg Med Chem Lett ; 12(24): 3561-3, 2002 Dec 16.

Article in En | MEDLINE | ID: mdl-12443776

Subject(s)

Histamine Antagonists/chemical synthesis; Receptors, Histamine H3/drug effects; Animals; Brain Chemistry; Carboxylic Acids/chemical synthesis; Carboxylic Acids/pharmacology; Cyclopropanes/chemical synthesis; Cyclopropanes/pharmacology; Histamine Antagonists/pharmacology; Ligands; Methylhistamines/metabolism; Radioligand Assay; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Histamine H3 / Histamine Antagonists Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: Spain Country of publication: United kingdom

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