Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor.

Smakhtin, M Yu; Sever'yanova, L A; Konoplya, A I; Shveinov, I A

Smakhtin, M Yu; Sever'yanova, L A; Konoplya, A I; Shveinov, I A.

Affiliation

Smakhtin MY; Department of Pathophysiology, Kursk State Medical University. big@ksmu.kursknet.ru

Bull Exp Biol Med ; 133(6): 586-7, 2002 Jun.

Article in En | MEDLINE | ID: mdl-12447473

ABSTRACT

ABSTRACT

Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).

Subject(s)

Hepatocytes/drug effects; Immunosuppressive Agents/pharmacology; Oligopeptides/pharmacology; Amino Acid Sequence; Animals; Antibody Formation; Dose-Response Relationship, Immunologic; Hepatocytes/metabolism; Hypersensitivity, Delayed/prevention & control; Immunization, Passive; Immunosuppressive Agents/chemistry; Mice; Mice, Inbred CBA; Mitotic Index; Oligopeptides/chemistry; Rats; Rats, Wistar

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Hepatocytes / Immunosuppressive Agents Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2002 Document type: Article

Search on Google

Add to My VHL

XML

PubMed Links