Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia.
J Infect Dis
; 186(12): 1790-6, 2002 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-12447765
ABSTRACT
Bronchoalveolar lavage fluid recovered from infected and uninvolved lungs of patients with community-acquired pneumonia (CAP; n=16) on day 6+/-0.8 was analyzed for cytokine, soluble receptor, and antagonist levels. The role of tumor necrosis factor (TNF)-alpha-converting enzyme (TACE) in the resolution of the local inflammatory response was investigated. TNF-alpha, interleukin (IL)-1beta, and IL-6 were elevated in the infected versus uninvolved lobe, whereas IL-10 was not. Epithelial lining fluid (ELF) cytokine levels correlated with intracellular cytokine expression. Levels of proTNF-alpha were reciprocally related to TNF-alpha ELF levels. Levels of soluble receptors, generated by TACE cleavage of membrane-bound precursors, were compartmentalized to infected ELF. TACE was down-regulated by internalization in cells from the site of infection. These data demonstrate that, in vivo during CAP, TACE has a role in regulating resolution of the local inflammatory response by modulating levels of pro- and counterinflammatory mediators.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia
/
Metalloendopeptidases
/
Community-Acquired Infections
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Infect Dis
Year:
2002
Document type:
Article
Affiliation country:
Ireland