Detection and isolation of equine herpesviruses 1 and 4 from horses in Normandy: an autopsy study of tissue distribution in relation to vaccination status.
J Vet Med B Infect Dis Vet Public Health
; 49(8): 394-9, 2002 Oct.
Article
in En
| MEDLINE
| ID: mdl-12449249
ABSTRACT
Equine herpesviruses type 1 and 4 (EHV-1 and EHV-4) are ubiquitous in the equine population. One of their main properties is their ability to establish life-long latent infections in their hosts even in those with natural or vaccine-induced immunity. However, effect of vaccination status on prevalence and tissue tropism was not established. In this study, EHV-1 and EHV-4 were detected by polymerase chain reaction and by classical virus isolation from neural, epithelial and lymphoid tissues collected from unvaccinated (33) or vaccinated (23) horses. The percentage of EHV-1- and EHV-4-positive horses between vaccinates and unvaccinates was similar. Both viruses were detected in all tissues of both groups; in particular, lymph nodes draining the respiratory tract, nasal epithelium and nervous ganglia [i.e. trigeminal ganglia (TG)], which represent the main positive sites for EHV-1 and EHV-4. In vaccinated animals, the nervous ganglia (i.e. TG) were less frequently positive than in unvaccinated animals. Detection of positive TG was strongly correlated to the presence of EHV-1 in nasal epithelium.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Vaccines
/
Herpesvirus 1, Equid
/
Herpesviridae Infections
/
Herpesvirus 4, Equid
/
Horse Diseases
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Animals
Country/Region as subject:
Europa
Language:
En
Journal:
J Vet Med B Infect Dis Vet Public Health
Journal subject:
MEDICINA VETERINARIA
/
SAUDE PUBLICA
Year:
2002
Document type:
Article
Affiliation country:
France