[Expression of HIF-1 alpha and its relationship to apoptosis and proliferation in lung cancer].
Ai Zheng
; 21(3): 254-8, 2002 Mar.
Article
in Zh
| MEDLINE
| ID: mdl-12451989
ABSTRACT
BACKGROUND & OBJECTIVES:
Hipoxia-inducible factor-1 is a transcriptive factor that regulates genes involved in metabolism, angiogenesis, proliferation, and apoptosis. This study was designed to investigate the expression of hypoxia inducible facter-1 alpha(HIF-1 alpha) and its relationship to bcl-2, Bax, PCNA in lung cancer.METHOD:
Immunohistochemical streptavidin/peroxidase(SP) was used to examine the expression of HIF-1a, bcl-2, Bax, and PCNA in 60 cases of lung cancer.RESULTS:
In 60 cases of lung cancer, positive rate for HIF-1a was 28.3% (17/60), specially the positive rate of small cell lung cancer(66.7%) was significantly higher than non-small cell lung cancer (21.6%). HIF-1a expression increased as clinical stage and metastasis increased(P < 0.01). The positive rate of bcl-2, Bax, and PCNA were 31.7% (19/60), 40.0% (24/60), 76.7% (46/60), respectively. Inverse relationship was found between the expression of HIF-1 alpha and bcl-2; while the correlation of HIF-1 alpha and Bax was positive(P < 0.01). The relationship between HIF-1 alpha and Bax was positive(P < 0.01). The relationship between HIF-1 alpha and PCNA was not observed(P > 0.05).CONCLUSION:
HIF-1 alpha is correlated with apopotosis, but has no relationship with proliferation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Apoptosis
/
Lung Neoplasms
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Ai Zheng
Journal subject:
NEOPLASIAS
Year:
2002
Document type:
Article