5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved.

López, José M; Santidrián, Antonio F; Campàs, Clara; Gil, Joan

López, José M; Santidrián, Antonio F; Campàs, Clara; Gil, Joan.

Affiliation

López JM; Unitat de Bioquímica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Campus de Bellvitge, E-08907 L'Hospitalet, Spain. jose.lopez@crg.es

Biochem J ; 370(Pt 3): 1027-32, 2003 Mar 15.

Article in En | MEDLINE | ID: mdl-12452797

Subject(s)

Aminoimidazole Carboxamide/analogs & derivatives; Aminoimidazole Carboxamide/pharmacology; Apoptosis/drug effects; Cyclic AMP-Dependent Protein Kinases/metabolism; Ribonucleosides/pharmacology; Thioinosine/analogs & derivatives; Adenosine/pharmacology; Affinity Labels/pharmacology; Amino Acid Chloromethyl Ketones/metabolism; Apoptosis/physiology; Caspases/metabolism; Cytochrome c Group/metabolism; Enzyme Inhibitors/metabolism; Humans; Jurkat Cells; Phosphorylation; Thioinosine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleosides / Thioinosine / Apoptosis / Cyclic AMP-Dependent Protein Kinases / Aminoimidazole Carboxamide Limits: Humans Language: En Journal: Biochem J Year: 2003 Document type: Article Affiliation country: Spain

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