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Multidrug resistance in ovarian cancer: comparing an immunocytochemical study and ATP-tumor chemosensitivity assay.
Raspollini, M R; Pinzani, P; Pazzagli, M; Baroni, G; Taddei, A; Amunni, G; Villanucci, A; Taddei, G L.
Affiliation
  • Raspollini MR; Department of Human Pathology and Oncology, University of Florence, Florence, Italy.
J Chemother ; 14(5): 518-25, 2002 Oct.
Article in En | MEDLINE | ID: mdl-12462432
ABSTRACT
The aim of our study was to evaluate the possible prognostic and predictive significance of the expression of P-glycoprotein, a transmembrane transport protein related to multidrug resistance, in previously untreated patients with FIGO stage III ovarian cancer; to compare the results of immunocytochemical analysis of tissue sections of tumors to the in vitro chemosensitivity to cytotoxic drug of fresh samples of the same tumors; and to evaluate survival in women who underwent the same surgical treatment and the same adjuvant chemotherapy.
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Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Carcinoma / Antineoplastic Combined Chemotherapy Protocols / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple / Genes, MDR Type of study: Evaluation_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: J Chemother Journal subject: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Year: 2002 Document type: Article Affiliation country: Italy
Search on Google
Add to My VHL
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Carcinoma / Antineoplastic Combined Chemotherapy Protocols / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple / Genes, MDR Type of study: Evaluation_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: J Chemother Journal subject: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Year: 2002 Document type: Article Affiliation country: Italy