Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.

Bradshaw, Tracey D; Bibby, Michael C; Double, John A; Fichtner, Iduna; Cooper, Patricia A; Alley, Michael C; Donohue, Susan; Stinson, Sherman F; Tomaszewjski, Joseph E; Sausville, Edward A; Stevens, Malcolm F G

Bradshaw, Tracey D; Bibby, Michael C; Double, John A; Fichtner, Iduna; Cooper, Patricia A; Alley, Michael C; Donohue, Susan; Stinson, Sherman F; Tomaszewjski, Joseph E; Sausville, Edward A; Stevens, Malcolm F G.

Affiliation

Bradshaw TD; Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom.

Mol Cancer Ther ; 1(4): 239-46, 2002 Feb.

Article in En | MEDLINE | ID: mdl-12467219

Subject(s)

Amino Acids/metabolism; Aniline Compounds/therapeutic use; Antineoplastic Agents/therapeutic use; Mammary Neoplasms, Experimental/drug therapy; Ovarian Neoplasms/drug therapy; Thiazoles/therapeutic use; Aniline Compounds/pharmacokinetics; Animals; Antineoplastic Agents/pharmacokinetics; Benzothiazoles; Blotting, Western; Cell Division/drug effects; Cytochrome P-450 CYP1A1/metabolism; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Male; Mammary Neoplasms, Experimental/enzymology; Mice; Mice, Nude; Ovarian Neoplasms/enzymology; Prodrugs; Rats; Rats, Sprague-Dawley; Thiazoles/pharmacokinetics; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Thiazoles / Amino Acids / Aniline Compounds / Mammary Neoplasms, Experimental / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2002 Document type: Article Affiliation country: United kingdom Country of publication: United States

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