Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells.

Waters, Catherine; Sambi, Balwinder; Kong, Kok-Choi; Thompson, Dawn; Pitson, Stuart M; Pyne, Susan; Pyne, Nigel J

Waters, Catherine; Sambi, Balwinder; Kong, Kok-Choi; Thompson, Dawn; Pitson, Stuart M; Pyne, Susan; Pyne, Nigel J.

Affiliation

Waters C; Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow, G4 0NR, Scotland, United Kingdom.

J Biol Chem ; 278(8): 6282-90, 2003 Feb 21.

Article in En | MEDLINE | ID: mdl-12480944

Subject(s)

Lysophospholipids; Muscle, Smooth/physiology; Receptor, Platelet-Derived Growth Factor beta/physiology; Receptors, Cell Surface/physiology; Receptors, G-Protein-Coupled; Sphingosine/analogs & derivatives; Sphingosine/physiology; Animals; Cells, Cultured; Guinea Pigs; Kinetics; MAP Kinase Signaling System/drug effects; MAP Kinase Signaling System/physiology; Mitogen-Activated Protein Kinases/metabolism; Muscle, Smooth/drug effects; Receptor, Platelet-Derived Growth Factor beta/drug effects; Receptors, Cell Surface/drug effects; Receptors, Lysophospholipid; Recombinant Proteins/drug effects; Recombinant Proteins/metabolism; Respiratory Physiological Phenomena; Sphingosine/pharmacology; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Lysophospholipids / Receptors, Cell Surface / Receptor, Platelet-Derived Growth Factor beta / Receptors, G-Protein-Coupled / Muscle, Smooth Limits: Animals Language: En Journal: J Biol Chem Year: 2003 Document type: Article Affiliation country: United kingdom Country of publication: United States

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