Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations.

Visser, S A G; Wolters, F L C; Gubbens-Stibbe, J M; Tukker, E; Van Der Graaf, P H; Peletier, L A; Danhof, M

Visser, S A G; Wolters, F L C; Gubbens-Stibbe, J M; Tukker, E; Van Der Graaf, P H; Peletier, L A; Danhof, M.

Affiliation

Visser SA; Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.

J Pharmacol Exp Ther ; 304(1): 88-101, 2003 Jan.

Article in En | MEDLINE | ID: mdl-12490579

Subject(s)

Electroencephalography/drug effects; GABA Modulators/pharmacology; Receptors, GABA-A/drug effects; Algorithms; Animals; Azabicyclo Compounds; Benzodiazepines/pharmacology; Carbolines/pharmacology; Chromatography, High Pressure Liquid; Convulsants/pharmacology; GABA Agonists/pharmacology; Hypnotics and Sedatives/pharmacology; In Vitro Techniques; Infusions, Intravenous; Male; Models, Biological; Piperazines/pharmacology; Protein Binding; Pyridines/pharmacology; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Zolpidem

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, GABA-A / GABA Modulators / Electroencephalography Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2003 Document type: Article Affiliation country: Netherlands Country of publication: United States

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