Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.

Gomez-Isla, Teresa; Irizarry, Michael C; Mariash, Ami; Cheung, Bonnie; Soto, Oscar; Schrump, Stefanie; Sondel, Jesse; Kotilinek, Linda; Day, John; Schwarzschild, Michael A; Cha, Jang-Ho J; Newell, Kathy; Miller, David W; Uéda, Kenji; Young, Anne B; Hyman, Bradley T; Ashe, Karen H

Gomez-Isla, Teresa; Irizarry, Michael C; Mariash, Ami; Cheung, Bonnie; Soto, Oscar; Schrump, Stefanie; Sondel, Jesse; Kotilinek, Linda; Day, John; Schwarzschild, Michael A; Cha, Jang-Ho J; Newell, Kathy; Miller, David W; Uéda, Kenji; Young, Anne B; Hyman, Bradley T; Ashe, Karen H.

Affiliation

Gomez-Isla T; Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.

Neurobiol Aging ; 24(2): 245-58, 2003.

Article in En | MEDLINE | ID: mdl-12498958

Subject(s)

Dopamine/physiology; Gliosis/pathology; Movement Disorders/pathology; Nerve Tissue Proteins/genetics; Parkinson Disease/pathology; Animals; Biomarkers; Blotting, Western; Electromyography; Female; Gene Expression; Gliosis/genetics; Gliosis/physiopathology; Humans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Movement Disorders/genetics; Movement Disorders/physiopathology; Nerve Tissue Proteins/analysis; Parkinson Disease/genetics; Parkinson Disease/physiopathology; RNA, Messenger/analysis; Substantia Nigra/enzymology; Substantia Nigra/pathology; Synucleins; Tyrosine 3-Monooxygenase/analysis; alpha-Synuclein

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Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Dopamine / Gliosis / Movement Disorders / Nerve Tissue Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Neurobiol Aging Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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