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The CD8alpha gene locus is regulated by the Ikaros family of proteins.
Harker, Nicola; Naito, Taku; Cortes, Marta; Hostert, Arnd; Hirschberg, Sandra; Tolaini, Mauro; Roderick, Kathleen; Georgopoulos, Katia; Kioussis, Dimitris.
Affiliation
  • Harker N; Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, NW7 1AA, London, United Kingdom.
Mol Cell ; 10(6): 1403-15, 2002 Dec.
Article in En | MEDLINE | ID: mdl-12504015
ABSTRACT
Ikaros family members are important regulatory factors in lymphocyte development. Here we show that Ikaros may play an important role in CD4 versus CD8 lineage commitment decisions by demonstrating (1) that it binds to regulatory elements in the endogenous CD8alpha locus in vivo using thymocyte chromatin immunoprecipitations, (2) that Ikaros suppresses position effect variegation of transgenes driven by CD8 regulatory elements, and (3) that mice with reduced levels of Ikaros and Aiolos show an apparent increase in CD4 populations with immature phenotype, i.e., cells that failed to activate the CD8alpha gene locus. We propose that Ikaros family members function as activators of the CD8alpha gene locus and that their associated activities are critical for appropriate chromatin remodeling transitions during thymocyte differentiation and lineage commitment.
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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Lymphocytes / T-Lymphocytes / Multigene Family / CD8 Antigens / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2002 Document type: Article Affiliation country: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Lymphocytes / T-Lymphocytes / Multigene Family / CD8 Antigens / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2002 Document type: Article Affiliation country: United kingdom