Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target.

Hochgürtel, Matthias; Biesinger, Ralf; Kroth, Heiko; Piecha, Dorothea; Hofmann, Michael W; Krause, Sonja; Schaaf, Otmar; Nicolau, Claude; Eliseev, Alexey V

Hochgürtel, Matthias; Biesinger, Ralf; Kroth, Heiko; Piecha, Dorothea; Hofmann, Michael W; Krause, Sonja; Schaaf, Otmar; Nicolau, Claude; Eliseev, Alexey V.

Affiliation

Hochgürtel M; Therascope AG, Im Neuenheimer Feld 584, 69120 Heidelberg, Germany.

J Med Chem ; 46(3): 356-8, 2003 Jan 30.

Article in En | MEDLINE | ID: mdl-12540234

Subject(s)

Enzyme Inhibitors/chemistry; Ketones/chemistry; Neuraminidase/antagonists & inhibitors; Amines/chemistry; Combinatorial Chemistry Techniques; Databases, Factual; Ligands; Neuraminidase/chemistry; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Ketones / Neuraminidase Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Document type: Article Affiliation country: Germany Country of publication: United States

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