Separation of albendazole sulfoxide enantiomers by chiral supercritical-fluid chromatography.
J Biochem Biophys Methods
; 54(1-3): 339-45, 2002 Dec 31.
Article
in En
| MEDLINE
| ID: mdl-12543509
The enantioseparation of albendazole sulfoxide (ABZSO) by chiral supercritical-fluid chromatography (SFC) on two columns, based on the polysaccharide derivatives Chiralpak AD and Chiralcel OD, was studied. The effect of different modifiers, methanol, ethanol, 2-propanol, and acetonitrile, was examined. The results showed that ABZSO can be separated on both columns, using an alcohol-type modifier. Using the Chiralpak AD column, the best results were obtained with 2-propanol and, in the case of the Chiralcel OD, with methanol.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Albendazole
/
Cellulose
/
Chromatography, Supercritical Fluid
/
Phenylcarbamates
/
Amylose
Type of study:
Diagnostic_studies
/
Evaluation_studies
Language:
En
Journal:
J Biochem Biophys Methods
Year:
2002
Document type:
Article
Affiliation country:
Spain
Country of publication:
Netherlands