Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

Nichols, Ralph C; Cooper, Sandra; Trask, Heidi W; Gorman, Nadia; Dalton, Timothy P; Nebert, Daniel W; Sinclair, Jacqueline F; Sinclair, Peter R

Nichols, Ralph C; Cooper, Sandra; Trask, Heidi W; Gorman, Nadia; Dalton, Timothy P; Nebert, Daniel W; Sinclair, Jacqueline F; Sinclair, Peter R.

Affiliation

Nichols RC; VA Medical Center, 215 N. Main Street, White River Junction, VT 05009, USA. ralph.c.nichols@dartmouth.edu

Biochem Pharmacol ; 65(4): 545-50, 2003 Feb 15.

Article in En | MEDLINE | ID: mdl-12566081

Subject(s)

Carcinoma, Hepatocellular/metabolism; Cytochrome P-450 CYP1A2/physiology; Porphyria Cutanea Tarda/enzymology; Uroporphyrins/metabolism; Aminolevulinic Acid/pharmacology; Animals; Cytochrome P-450 CYP1A2/biosynthesis; Cytochrome P-450 CYP1A2/genetics; Cytochrome P-450 Enzyme System/metabolism; Humans; Immunoblotting; Mice; Oxidoreductases/metabolism; Porphyria Cutanea Tarda/metabolism; Transfection; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Uroporphyrins / Porphyria Cutanea Tarda / Carcinoma, Hepatocellular / Cytochrome P-450 CYP1A2 Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2003 Document type: Article Affiliation country: United States

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