NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.

Sen, Pradip; Bhattacharyya, Sandip; Wallet, Mark; Wong, Carmen P; Poligone, Brian; Sen, Maitreyee; Baldwin, Albert S; Tisch, Roland

Sen, Pradip; Bhattacharyya, Sandip; Wallet, Mark; Wong, Carmen P; Poligone, Brian; Sen, Maitreyee; Baldwin, Albert S; Tisch, Roland.

Affiliation

Sen P; Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

J Immunol ; 170(4): 1770-80, 2003 Feb 15.

Article in En | MEDLINE | ID: mdl-12574341

Subject(s)

Antigen-Presenting Cells/immunology; Antigen-Presenting Cells/metabolism; Diabetes Mellitus, Type 1/immunology; Macrophages/immunology; Macrophages/metabolism; NF-kappa B/metabolism; Adjuvants, Immunologic/antagonists & inhibitors; Adjuvants, Immunologic/metabolism; Adjuvants, Immunologic/physiology; Animals; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Cells, Cultured; Cytokines/metabolism; Diabetes Mellitus, Type 1/metabolism; Female; I-kappa B Proteins/metabolism; Lymphocyte Activation/immunology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Transgenic; NF-KappaB Inhibitor alpha; NF-kappa B/antagonists & inhibitors; NF-kappa B/physiology; Species Specificity; Spleen/cytology; Spleen/immunology; Spleen/metabolism; Up-Regulation/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Diabetes Mellitus, Type 1 / Macrophages / Antigen-Presenting Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2003 Document type: Article Affiliation country: United States

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