Steric-control for the enantioselective hydrolysis of amino acid esters in hybrid membrane systems.
Chem Pharm Bull (Tokyo)
; 51(2): 224-6, 2003 Feb.
Article
in En
| MEDLINE
| ID: mdl-12576664
ABSTRACT
The enantioselective hydrolysis of the amino acid esters, p-nitrophenyl-N-dodecanoyl-D(L)-phenylalaninates (C(12)-D(L)-Phe-PNP) catalyzed by active tripeptide, N-(benzyloxycarbonyl)-L-phenylalanyl-L-histidyl-L-leucine (Z-PheHisLeu) in the presence of coaggregates (hybrid membranes) composed of native phospholipid, L-alpha-dimyristoylphosphatidylcholine (DMPC) and nonionic surfactant, polyoxyethylene (8) lauryl ether (C(12)(EO)(8)) was easily controlled by regulating the reaction temperature and changing the composition of coaggregates. Furthermore, excellent correlations were observed between the enantioselectivity in the hydrolysis of C(12)-D(L)-Phe-PNP catalyzed by Z-PheHisLeu in the presence of coaggregates and physical properties of hybrid membranes. It is assumed that catalytic activities of tripeptide catalyst in hybrid membranes should be regulated by changing the microenvironments of reaction fields.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amino Acids
/
Membranes, Artificial
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2003
Document type:
Article
Affiliation country:
Japan