A new crystal form of nateglinide.

AIM: To find a new crystal structure of S-form in nateglinide [N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine]. The XRD, IR patterns and data were given and the melting point was determined. METHODS: Phase analysis was performed by X-ray powder diffraction, IR and elemental analysis and the melting point was determined by differential scan calorimetry. RESULTS: S-form nateglinide is different from H-form or B-form. The melting point is 172.04 degrees C. CONCLUSION: The S-form nateglinide is a new crystal form.