Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity.

Tonomura, Noriko; McLaughlin, Kelly; Grimm, Lisa; Goldsby, Richard A; Osborne, Barbara A

Tonomura, Noriko; McLaughlin, Kelly; Grimm, Lisa; Goldsby, Richard A; Osborne, Barbara A.

Affiliation

Tonomura N; Department of Veterinary and Animal Sciences and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.

J Immunol ; 170(5): 2469-78, 2003 Mar 01.

Article in En | MEDLINE | ID: mdl-12594272

Subject(s)

Acetylcysteine/administration & dosage; Apoptosis/drug effects; Cysteine Endopeptidases/physiology; Dexamethasone/administration & dosage; Mitochondria/enzymology; Multienzyme Complexes/physiology; Thymus Gland/cytology; Thymus Gland/drug effects; Animals; Apoptosis/immunology; Cell Death/immunology; Cells, Cultured; Cysteine Endopeptidases/metabolism; Female; Hydrogen Peroxide/metabolism; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mitochondria/drug effects; Mitochondria/immunology; Mitochondria/metabolism; Multienzyme Complexes/metabolism; Oxygen/physiology; Proteasome Endopeptidase Complex; Reactive Oxygen Species/pharmacology; Thymus Gland/enzymology; Thymus Gland/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Thymus Gland / Dexamethasone / Cysteine Endopeptidases / Apoptosis / Mitochondria / Multienzyme Complexes Limits: Animals Language: En Journal: J Immunol Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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