Type I interferons induce proteins susceptible to act as thyroid receptor (TR) corepressors and to signal the TR for destruction by the proteasome: possible etiology for unexplained chronic fatigue.

Englebienne, P; Verhas, M; Herst, C V; De Meirleir, K

Englebienne, P; Verhas, M; Herst, C V; De Meirleir, K.

Affiliation

Englebienne P; University of Brussels (ULB/VUB), N.V., Brussels, Belgium. penglebi@ulb.ac.be

Med Hypotheses ; 60(2): 175-80, 2003 Feb.

Article in En | MEDLINE | ID: mdl-12606231

Subject(s)

Cysteine Endopeptidases/metabolism; Fatigue Syndrome, Chronic/etiology; Interferon Type I/physiology; Multienzyme Complexes/metabolism; Receptors, Thyroid Hormone/metabolism; 2',5'-Oligoadenylate Synthetase/metabolism; Amino Acid Motifs; Amino Acid Sequence; DNA-Binding Proteins/metabolism; Humans; Interferon Type I/metabolism; Models, Biological; Molecular Sequence Data; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Signal Transduction

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Thyroid Hormone / Cysteine Endopeptidases / Interferon Type I / Fatigue Syndrome, Chronic / Multienzyme Complexes Type of study: Etiology_studies Limits: Humans Language: En Journal: Med Hypotheses Year: 2003 Document type: Article Affiliation country: Belgium Country of publication: United States

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