Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling.

Borchers, Michael T; Biechele, T; Justice, J P; Ansay, T; Cormier, S; Mancino, V; Wilkie, T M; Simon, M I; Lee, N A; Lee, J J

Borchers, Michael T; Biechele, T; Justice, J P; Ansay, T; Cormier, S; Mancino, V; Wilkie, T M; Simon, M I; Lee, N A; Lee, J J.

Affiliation

Borchers MT; Department of Biochemistry and Molecular Biology, SCJMRB-Research, Mayo Clinic Scottsdale, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA.

Am J Physiol Lung Cell Mol Physiol ; 285(1): L114-20, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12611815

Subject(s)

Bronchial Hyperreactivity/physiopathology; Bronchoconstrictor Agents/pharmacology; Heterotrimeric GTP-Binding Proteins/genetics; Heterotrimeric GTP-Binding Proteins/metabolism; Methacholine Chloride/pharmacology; Airway Resistance/physiology; Allergens/pharmacology; Animals; Bronchial Hyperreactivity/chemically induced; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth/drug effects; Muscle, Smooth/physiopathology; Ovalbumin/pharmacology; Signal Transduction/physiology; Trachea/drug effects; Trachea/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Bronchoconstrictor Agents / Methacholine Chloride / Bronchial Hyperreactivity / Heterotrimeric GTP-Binding Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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