Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety.

Baraldi, Pier Giovanni; Beria, Italo; Cozzi, Paolo; Bianchi, Nicoletta; Gambari, Roberto; Romagnoli, Romeo

Baraldi, Pier Giovanni; Beria, Italo; Cozzi, Paolo; Bianchi, Nicoletta; Gambari, Roberto; Romagnoli, Romeo.

Affiliation

Baraldi PG; Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy.

Bioorg Med Chem ; 11(6): 965-75, 2003 Mar 20.

Article in En | MEDLINE | ID: mdl-12614881

Subject(s)

Antibiotics, Antineoplastic/chemical synthesis; Antibiotics, Antineoplastic/pharmacology; Distamycins/chemical synthesis; Distamycins/pharmacology; Acids, Heterocyclic/chemical synthesis; Acids, Heterocyclic/pharmacology; Animals; Cell Division/drug effects; DNA Footprinting; DNA, Neoplasm/biosynthesis; Deoxyribonuclease I/chemistry; Doxorubicin/pharmacology; Drug Design; Drug Screening Assays, Antitumor; Indicators and Reagents; Leukemia L1210/drug therapy; Leukemia L1210/pathology; Magnetic Resonance Spectroscopy; Mice; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Distamycins / Antibiotics, Antineoplastic Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: Italy

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