Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer.

Hofheinz, R-D; al-Batran, S-E; Hartmann, F; Hartung, G; Jäger, D; Renner, C; Tanswell, P; Kunz, U; Amelsberg, A; Kuthan, H; Stehle, G

Hofheinz, R-D; al-Batran, S-E; Hartmann, F; Hartung, G; Jäger, D; Renner, C; Tanswell, P; Kunz, U; Amelsberg, A; Kuthan, H; Stehle, G.

Affiliation

Hofheinz RD; Onkologisches Zentrum, III. Medizinische Klinik, Universitätsklinikum Mannheim, Germany. ralf.hofheinz@med3.ma.uni-heidelberg.de

Onkologie ; 26(1): 44-8, 2003 Feb.

Article in En | MEDLINE | ID: mdl-12624517

Subject(s)

Antibodies, Monoclonal/therapeutic use; Biomarkers, Tumor/antagonists & inhibitors; Colorectal Neoplasms/drug therapy; Liver Neoplasms/secondary; Lung Neoplasms/secondary; Aged; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Colorectal Neoplasms/blood; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Endopeptidases; Female; Follow-Up Studies; Gelatinases; Humans; Infusions, Intravenous; Liver Neoplasms/blood; Liver Neoplasms/drug therapy; Lung Neoplasms/blood; Lung Neoplasms/drug therapy; Male; Membrane Proteins; Middle Aged; Palliative Care; Serine Endopeptidases; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor / Liver Neoplasms / Lung Neoplasms / Antibodies, Monoclonal Type of study: Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Onkologie Year: 2003 Document type: Article Affiliation country: Germany Country of publication: Switzerland

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