Single- and multiple-dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, in man.

Agrawal, Nancy G B; Porras, Arturo G; Matthews, Catherine Z; Rose, Mark J; Woolf, Eric J; Musser, Bret J; Dynder, Andrea L; Mazina, Katherine E; Lasseter, Kenneth C; Hunt, Thomas L; Schwartz, Jules I; McCrea, Jacqueline B; Gottesdiener, Keith M

Agrawal, Nancy G B; Porras, Arturo G; Matthews, Catherine Z; Rose, Mark J; Woolf, Eric J; Musser, Bret J; Dynder, Andrea L; Mazina, Katherine E; Lasseter, Kenneth C; Hunt, Thomas L; Schwartz, Jules I; McCrea, Jacqueline B; Gottesdiener, Keith M.

Affiliation

Agrawal NG; Department of Drug Metabolism, WP75-200, Merck Research Laboratories, West Point, PA 19486, USA.

J Clin Pharmacol ; 43(3): 268-76, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12638395

Subject(s)

Cyclooxygenase Inhibitors/pharmacokinetics; Isoenzymes/antagonists & inhibitors; Pyridines/pharmacokinetics; Sulfones/pharmacokinetics; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/administration & dosage; Cyclooxygenase Inhibitors/adverse effects; Dietary Fats; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoricoxib; Fasting; Female; Food-Drug Interactions; Humans; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Pyridines/administration & dosage; Pyridines/adverse effects; Sulfones/administration & dosage; Sulfones/adverse effects; Tablets; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Sulfones / Cyclooxygenase Inhibitors / Isoenzymes Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2003 Document type: Article Affiliation country: United States Country of publication: United kingdom

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