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Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
Tellew, John E; Baska, Rose Ann F; Beyer, Sophie M; Carlson, Kenneth E; Cornelius, Lyndon A; Fadnis, Leena; Gu, Zhengxiang; Kunst, Bridgette L; Kowala, Mark C; Monshizadegan, Hossain; Murugesan, Natesan; Ryan, Carol S; Valentine, Maria T; Yang, Yifan; Macor, John E.
Affiliation
  • Tellew JE; Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-5400, USA. jtellew@neurocrine.com
Bioorg Med Chem Lett ; 13(6): 1093-6, 2003 Mar 24.
Article in En | MEDLINE | ID: mdl-12643919
ABSTRACT
A series of 4'-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT(1) and endothelin ET(A) receptors. Such dual-acting antagonists could have utility in the treatment of hypertension, heart failure, and other cardiovascular diseases in a broad patient population. Certain compounds in the present series are orally active in a rat model of angiotensin II-mediated hypertension.
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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Biphenyl Compounds / Angiotensin Receptor Antagonists / Endothelin Receptor Antagonists Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United States
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Biphenyl Compounds / Angiotensin Receptor Antagonists / Endothelin Receptor Antagonists Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United States