High susceptibility of human leukemic cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment.

Jedema, I; Barge, R M Y; Willemze, R; Falkenburg, J H F

Jedema, I; Barge, R M Y; Willemze, R; Falkenburg, J H F.

Affiliation

Jedema I; Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, The Netherlands.

Leukemia ; 17(3): 576-84, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12646947

Subject(s)

Apoptosis/drug effects; G1 Phase/drug effects; Interferons/pharmacology; Leukemia, Myeloid/pathology; fas Receptor/physiology; Cell Cycle/drug effects; Cell Cycle/physiology; G1 Phase/physiology; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Humans; Immunophenotyping; Time Factors; Tumor Cells, Cultured; fas Receptor/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid / G1 Phase / Interferons / Apoptosis / Fas Receptor Type of study: Prognostic_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2003 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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