Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression.

Tsuji, S; Morinobu, S; Tanaka, K; Kawano, K; Yamawaki, S

Tsuji, S; Morinobu, S; Tanaka, K; Kawano, K; Yamawaki, S.

Affiliation

Tsuji S; Department of Psychiatry, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan.

J Neural Transm (Vienna) ; 110(4): 413-25, 2003 Apr.

Article in En | MEDLINE | ID: mdl-12658368

Subject(s)

Brain/drug effects; Lithium Chloride/pharmacology; Phosphoprotein Phosphatases/metabolism; Valproic Acid/pharmacology; Animals; Brain/enzymology; Enzyme Activation/drug effects; Enzyme Induction/drug effects; Enzyme Induction/physiology; Gene Expression Regulation, Enzymologic/drug effects; Male; Phosphoprotein Phosphatases/biosynthesis; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Valproic Acid / Lithium Chloride / Phosphoprotein Phosphatases Limits: Animals Language: En Journal: J Neural Transm (Vienna) Year: 2003 Document type: Article Affiliation country: Japan Country of publication: Austria

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